Filed under: chemicals, EU Information | Tags: endocrine disrupters, toxicity testing
The European Food Safety Authority, EFSA, has published a scientific opinion on the hazard assessment of endocrine disrupters (EDCs). EDCs work on 4 established endocrine pathways in organisms to disrupt the endocrine system.
There is no single test to establish if a substance is an endocrine disrupter, so testing needs to be carried out in a systematic manner in order to establish whether a substance is an EDC. EFSA is particularly concerned with EDCs which may be present in the food chain, e.g. pesticides.
EFSA has concluded that a risk assessment approach which considers both potential adverse effects of endocrine active substances together with the likelihood of exposure makes best use of available information to regulate their use.
The full report is available here.
Interpol and pharmaceutical companies are taking action together to face down the problem of counterfeit medicines.
The problem of counterfeit medicines being so readily available is truly international in scale, and in some developing countries as much as 50% of all medicines purchased are counterfeit. Counterfeit products not only lack the active ingredients they need to be effective, some actually contain substances which are positively injurious to human health.
Testing of suspected counterfeit medicines is important in this fight; it can be relatively straightforward to determine the level of active ingredients in a pharmaceutical product, but to determine what else may be present in a fake medicine requires more extensive work.
Filed under: chemicals, EU Information, Forensics | Tags: chemicals, forensics
The European Union has decided that the substance 4-methylamphetamine, used illicitly as a stimulant drug, shall be subject to control measures. Commission Decision 2013/129/EU details the case for this.
Although research into the risks of taking this substance are limited there are clear indications of a number of adverse effects to users. There have been a number of deaths across the EU where post-mortems have indicated that 4-methylamphetamine may have been a contributory factor.
The ban on the marketing of cosmetics, and cosmetic ingredients, which have been subject to animal testing as part of their safety assessment, came into force today, 13 March 2013. A question and answer document from the European Commission can be found here on the subject.
Significant work is being carried out to develop and validate alternative testing methods for cosmetics and cosmetic ingredients which do not involve animal testing.
Filed under: Environment/Ecology, Government Chemist Information | Tags: Government Chemist reports, Speciation
A new report has been published on the Government Chemist website on qualitative determination of chromium species by liquid chromatography- inductively coupled plasma mass spectrometry (LC-ICPMS). This follows on from similar work undertaken on arsenic species in 2010 and 2012.
The method can separate, and potentially quantify, chromium species including Cr (III) and the more toxic Cr (VI) and has the potential to be used in environmental testing, food testing and cosmetics testing.
The European Chemicals Agency, ECHA, has launched a consultation to identify a further 10 chemicals as substances of very high concern (SVHCs).
ECHA are seeking comments and information relating to the use of these substances and the amount manufactured in the EU. The information will help decide whether any of these substances will be included in the Candidate List of SVHCs in future. The substances covered by this consultation are:
- Cadmium oxide
- Dipentyl phthalate (DPP)
- 4-Nonylphenol, branched and linear, ethoxylated
- 2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350)
- 2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328)
- 2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327)
- 2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320)
- Ammonium pentadecafluorooctanoate (APFO), and
- Pentadecafluorooctanoic acid (PFOA)