New Class A Drugs listed under Misuse of Drugs Act by Nick Boley
February 24, 2015, 09:11
Filed under: Drugs, Forensics, UK Legislation | Tags: ,

Two new substances have been listed as Class A drugs under the Misuse of Drugs Act 1971. The Misuse of Drugs Act 1971 (Amendment) Order 2015 (SI 215) brings under the permanent control of the Misuse of Drugs Act 1971 a potent opioid known as MT-45 and a synthetic stimulant known as 4,4’-DMAR as Class A drugs under the Act. This legislation is enacted in Northern Ireland by The Misuse of Drugs (Amendment) Regulations (Northern Ireland) 2015 (SR 53).

MT-45 has the systematic IUPAC name of 1-Cyclohexyl-4-(1,2-diphenylethyl)piperazine, and almost all its opioid activity resides in the (S) enantiomer. It is associated with hearing loss and unconsciousness.

MT-45 svg.svg   Structure of MT-45

4,4’-DMAR, or 4,4′-Dimethylaminorex, has the systematic IUPAC name of 4,5-Dihydro-4-methyl-5-(4-methylphenyl)-2-oxazolamine.

44dimethylaminorex structure.png  Structure of 4,4’-DMAR

This so-called “designer drug” is believed to have been responsible for many deaths in the EU over the last few years.

Analytical methods to detect and quantify these two substances must be added to the toolkit of the forensic science laboratories in the UK to properly enforce his new regulation. A reference material of 4,4’-DMAR is available from LGC Standards to help the forensic scientist in this regard. No reference material for MT-45 appears to be available as yet.


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